Adventure Gaming has meant for a long time that it's impossible to die or make a choice that irredeemably breaks your game. In days of ole, you could end up in unwinnable situations by not picking up an item (sometimes it was visible, sometimes it was hidden). This was largely phased out by LucasArts in favor of a gentler approach that allowed you to choose funny dialogue options and try everything without consequence.
Games in general have been getting easier across the gamut. While before Mario had 5 lives and had to go through each level in constant succession, now you can return to old levels to farm lives. Dying becomes less painful with every passing game. Instead of restarting the game, you lose 20 seconds of playtime. Games no longer punish players. There is Hard Normal and a new setting that makes enemies take your hand and walk you to the ending cinematic.
While there are a few examples of being able to screw yourself into a Game Over (silence in the Kenny fight scene is one), Telltale is probably going to avoid that as much as possible. It goes against Adventure Game rules and it's contrary to modern gaming.