It's something that Ben says after you rescue him in Episode 2 that may be a spoiler for the show and the comic. Other than that, the game and the show/comic star very different characters, not counting the cameos by two of the characters from the comics/show in the first Episode of the game. That won't spoil what goes on with those two characters after they leave the game, and actually provides a bit of backstory so you might understand them a bit better once you see them in the comic/show.
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