Originally Posted by StanleyStutters
Unless Lee is miraculously cured somehow, I think we'll see an entirely new group of people. Looking at who's left heading into EP5 the only one I could see as a lead character would be an older version of Clem, but I really doubt they go that way.
Lee being cured at all would kill the game. Also, Clem will probably become a walker and we'll have to shoot her by the end of Ep5 :]
I'm being optimistic.