Originally Posted by Jake
Lee cures the zombie apocalypse by creating a serum of his own design at the end of episode four*. He and Clementine find a working helicopter and learn to fly it together, blanketing America in anti-zombie spray, or "Marsh Spray," as it's called (reason for that name to be revealed later, I don't want spoilers here). Lee marries Lilly or Carley, depending on player choice. In a rare playthrough, Lee can also marry Katjaa by means I don't want to reveal yet (again, spoilers).
* If Doug is in your group to help you, the serum is developed one episode earlier.
That's pretty horrible, don't you think?
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