I predicted that Clem would eventually be put in a position where she would have to shoot and kill Lee. Guessed it, and even typed about it before Episode 3 was out (hurray for not being sad enough to boast about it in a new thread).
I could feel my eyes welling up in the final scene. Just after Clem helped me along near to the door. I felt that teaching Clem about your puzzle solving detracted from it a bit. Would've been nice to see how well we'd already taught her instead.
After she'd bashed the officers head in, it started to get emotional again. Held it together until the end. I was even talking to the screen, telling Clem not to shy out of pulling that trigger. About 10 seconds into the credits and I had some tears coming down my face.
Most games that play on emotions are lucky if they even get my eyes watering. I shed maybe 5 or 6 tears.
Now this is one piece of gaming media that I think the family might enjoy trying.