Done. Unfortunately, no change.
Just tried again with all manner of lowered settings etc. but no change. Crash at exactly the same moment still

It's a shame as it's quite far beyond the last checkpoint, so each time I want to try I have to sit through about 10 minutes of dialogue.
I guess all I can hope for right now is that there is a patch in the works. Has there been any indication from TT that they're aware of any Mac issues?
They announced an upcoming patch for the Xbox 360 version today.