No. No. No. That would be like 24 without Jack Bauer. That would be like TWD tv show without Rick. That would be like The Office without Micheal Scott (We all saw how well that worked for them).
A series is called a series because it follows the events of a person or group of people.
If Clem is left out what is the purpose of Season 1?
I feel it is Clementine who makes TWD game so great. There woudlnt be half the emotional toll on the audience without her. Sure there would be some "Holy Frick" moments, and some sad moments, But nothing like they are with Clem.
When the writers can make people cry, and feel angry and depressed over a situation, They know what they are doing. And Im sure we wouldnt be hearing, witnessing, or expressing those feelings if Lee just died, alone at the end of Season 1 without Clementine or her impact on him.
So Clem is a must for season 2.