According to developer Mike Stemmle (talking about spoiling the game spoiling the comics rather than the other way around, but his comments seem to imply that it works both ways):
Originally Posted by ttg_Stemmle
We're working REALLY hard to make the game NOT spoil the comics. In fact, the story we're telling is almost guaranteed not to spoil the comics. Make of that what you will
Personally, I find the first three volumes to be the perfect primers for what we're up to.
Mike "Writing Up a Storm" Stemmle