I always take the supplies from the car now, because Episode 5 doesn't make any goddamn sense to me if I don't, which I didn't on my original save. Funny story though, I got my saves wiped when Episode 5 came out, and when I got to that point in my replay, I almost decided to take them. "What the hell, it's not like this will ever matter beyond Clem looking cool with the hoodie" I said to myself. Boy was I glad I left them like I did originally, even if it didn't make much sense for him to question every single thing I did simply because my bro took his food.
Other than that, I don't really change up many things unless I'm trying to see what happens differently. I like the way my original game went very much, and it's kind of weird to play with more than a couple choices changed.