Even Maniac Mansion could be done as a CG movie, with the nice cartoonish style of DOTT. Perhaps a traditional animation feature would be even better, but I can't think of who would be the best to do it.
Please don't kill the image I have in my mind about MM/DOTT with a 3D version!
For (a maybe fat-fetched) example: I was really disgusted when I saw the poster for the Garfield movie - I will never watch it in my whole life... yuck. Garfield is a character composed of thick outlines and thin inlines - the first comic-strip that used this technique, AFAIK. They destroyed that style in the 3D-movie in creating a fat, furry, photorealistic cat - lacking all the finesse of the drawings.
The best team for a MM/DOTT movie would be Genndy Tartakovsky/David Feiss/Craig McKracken - or any other of the great Cartoon Network artists. (Dexter/PPG/Johnny Bravo/etc...)
Oh man, that would be one sweet movie!