well if it's running in safe mode, one thing you can try is a clean boot. That will turn off just about everything (much like safe mode). If that works, then it's a case of seeing which program is causing the problem. These steps are for vista, but hopefully they will work for Win7:
To Boot Clean in Windows Vista
1. Click Start --> Run --> Type MSCONFIG --> Click OK
2. On the General tab, choose Selective Startup
3. Uncheck Load Startup Items
4. Select the Services tab
5. Check Hide all Microsoft services
6. Click Disable all
7. Click on OK
8. Click Restart.
9. After reboot, run game to see if it works.
After performing the necessary steps, restore your system by doing the following:
1. Click Start --> Run --> Type MSCONFIG--> Click OK
2. On the General tab, choose Normal Startup
3. Click Ok
4. Click Yes, when asked to restart your computer
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