I fixed the problem on my PC...
I was getting a crash to the desktop at scene transitions when I ran in fullscreen mode. I have a Dell with an ATI X1400. I upgraded my graphics drivers to the new 6.12 version. The game now runs without any problems, and I can even run it at a slightly higher resolution than before without slow or jerky graphics.
The tricky part is that ATI won't let you download or install their standard drivers onto Dell PCs, and Dell hasn't come out with an updated custom driver since July. Normally in this situation I would get special custom drivers from Omega Drivers, but he's been awol since the 6.9 drivers. My final solution was to build custom .inf files for the ATI 6.12 drivers and then use the "update driver" Windows feature instead of the ATI installer.
I see that
www.ngohq.com now has custom ATI 6.12 drivers that should work on many different PCs, including Dells. I haven't ever tried these drivers, but it seems that many people use them.
The proper fix in this situation would be to get Dell to release updated custom drivers, but I've tried to get them to do it in the past without any luck, just more aggravation.