I want to see it turn out that Lee has some kind of immunity to the virus. It's not out of the realm of possibility. The television series has kind of implied that Rick is the same - that somehow a near death experience during the initial outbreak confers a degree of hardiness and possible immunity.
Which isn't to say he isn't still a carrier of the virus - just that it can't turn him. Viruses can act this way in real life as well. You can get people who are carriers but not sufferers of the virus.
So I expect that Lee will turn out to be immune to the virus and the story will be about whether he is able to save Clem along with as many of the survivors as he can.
I expect that Kenny will die regardless of action, but that Ben, Christa and Omid will remain determinable by your decisions. Kenny's death will possibly be a turning point that will be decided by how well you've treated him over the course of the series.
Those are my predictions anyway.