I posted this at Mojo, but it fits here too.
Lost would have made for wonderful episodic adventures a few seasons back, but now the show is wrapping up, there's a lot less appeal in unravelling more mysteries. We're going to get a conclusion in a few weeks. Why go back?
But not taking the Lost suggestions so literally, it bodes well for "serious" adventures with a big mystery, strange happenings, a dark and twisted theme. Just like Doctor Who, which Telltale has missed out on.
This style of game could be applied to other similar franchises though - X-Files, Fringe, V, Alien, Dark Crystal etc.
I've said it here before, but I'd love a Dark Crystal set of adventures to coincide with
the new movie if it ever gets out of development hell. In fact anything 'Henson' could make for a wonderful game, but I think the Dark Crystal world has the most potential.