I've seen quite a few, and yeah, there's usually a sharp and understated wit at play. It's not quite the same kind of funny as typical Sam & Max, but should be just as enjoyable for Telltale fans. Here are imdb links for two of my favorites:
Laura and
The Big Sleep. If you read the quotes sections you'll get a taste of film noir banter -- and its highly sexual undertones in the case of the latter movie. Which raises the question, Is there a Bacall for badass Sam's Bogey in Ep. 3?
What's weird is that I never realized, until these recent threads, that Ep. 3 was supposed to be film noir-esque -- because "They Stole Max's Brain" sounds more like a sci-fi B-movie.

Film noir titles are often rather mundane.