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Originally Posted by docma
This is probably going to be a useful link for you: http://walkingdead.wikia.com
AFAIK, neither the books nor the TV show get into the cause much. It's similar to Romero's movies - the dead rise, the few people remaining are too busy surviving to figure out why and the writers don't explain it in order to immerse their readers/viewers better into the human side of the story (IMO).
The TV series reveals that all the living are 'infected' - it's told to Rick by a CDC scientist at the end of the first season and Rick tells everyone else at the end of the second. Not sure if that's also in the books or not - don't think they ever went to the CDC. Note that 'infected' is just the interpretation the group puts on Rick's knowledge.
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*****DO NOT READ UNLESS YOU WANT THE T.V. SERIES AND COMICS RUINED!!!!
In the comics, rick goes back to shawns grave and digs him out to find he's alive after a run in withsome who had no bite marks. So the comic and the TV series are nearly 100% different, just the locations are the same (so far). They use the comics as a...guide-line, adding and removing key characters how they see fit instead of making people get so attached after 5 seasons then offing the person, they seem to prolong others and end them, and just make certain people none existant at all or show up/leave when ever.
In the TV series daryl and merl exist, and T-dog. They aren't in the comics. I doubt they will also make rick lose his hand to the gov. and merl has been in jail, and will end up being one of the cons they find at the prison. Since he was left for dead, he will probably be replacing the physco convict killer that mercs the little girls (who already left in the first season)....it's kind of weird how they did it, but it's slightly refreshing, aside from the way too much talking, unless they got that done so they could make the third season mostly about getting the prison and fighting woodsbury.
As for how it happened, use your imagination, it could have been made by communist in satist labs or terrorists, it doesn't take much to weaponize rabies and turn it into something super hard-core like this. People have been weaponizing diseases and viruses for years, anthrax, small pox, the black plague. You name it, we've probably did it. Or you can consider god got bored and wanted to be entertained! =p