Yeah, albeit a fantasy based game, I'll add my bits and pieces that don't add up to me, as well. Remember, it's only a game, so don't think too hard on these little tidbits I'm about to point out.
Guns: Okay, they're in Georgia. Being from a gun happy state myself, this bugs me a little. In Episode two, when the camera pans on Lily's face as she's staring off into the woods, before Lee and company bring Ben and his friend in, you can see her weapon. Now, I may be wrong, but judging by the size, magazine (It looked like a magazine at the bottom of the rifle), and so on... You mean to tell me Lily was using a .22 rifle? Really? That's all they could find? Even in Episode three, when Carly helps you in the Motor Inn raid, she seems to be using a 9mm semi-automatic (Pistols are harder to identify in games, but it looks like a 9mm to me). Is this all they could find?
In reality, they should have been tripping over guns, especially in Georgia. Southern states are known for their gun toting citizens (And there's nothing wrong with that). I find it really hard to believe that, with the majority of the population decimated by the outbreak, they only had those certain weapons after a 3+ month stay at the inn. Even one of the bandits had a shotgun, but Lee's crew are carrying light arms. Wow.
Food and Supplies: Again, this is another one that doesn't make sense to me. Even small towns have multiple eateries and stores to shop at, but after three months they still don't have squat for supplies. There doesn't seem to be too many other survivors in the immediate area, so I'd assume they'd be able to sneak around and gather much more food and supplies then they already have.
Gear: They have... nothing! Even Christa and Omid struck me as odd, walking around with nothing to their names, but these guys only have ONE backpack and no batteries. I'm sure the town wasn't cleaned out, especially with the lack of people, in three months. Speaking of the gear. Why does it look like they're using stuff from back in the early 90's? Incandescent bulb flashlights? No L.E.D.s? Nobody else carries a backpack? There should be tons of gear laying around. Same with food, and the other things.
The Chalk: What was the point of that? One "X" on a wall and some smashed chalk under the dumpster? Huh?

Was Ben marking the building, or something? Why? They already shot the crap out of it with bullets and arrows. I'm pretty sure they knew what motor inn they were at (Considering I didn't see another one). Besides, where did they get the chalk? I've never seen a pharmacy carry sticks of chalk before.
The Motor Inn: Okay, you mean to tell me that out of ALL of those vehicles, not a single one was operational? Was the inn run down and abandoned to begin with? The RV had to have worked at one time, and I assume no one did any real damage to it after the ZA broke out (People were too busy being dead

), but Kenny had to make major repairs to it. Right. I guess that would have been too easy for them, considering the story has to make it seem that they're hard-pressed.
The Tanker: This one struck me as odd for a few reasons. First, even though there weren't too many people out and about, there was still fuel in it. I would have thought that people would have stumbled across it, by now, and emptied the contents from the tanker at least. I would think that some survivors would have generators, and such, and would need the fuel. I'm surprised nobody stumbled across it.
Secondly, it seems to have been in an accident. However, looking at the scene, there's no evidence that that was the case. The vehicle (The one with the tape in it) was blocking the tanker's path, implying that it showed up afterward, but I saw no damage to the front of the semi pulling the tanks (Correct me if I'm wrong). How on earth did it go over the edge? When Lee was trying to cut through it, and it shifted, that went to prove (Since the tires rolled) that the brakes weren't on. Why didn't it just roll over the edge, as well? Lastly, on a small note, it would have taken them a lot longer to blowtorch their way through that hitch.
Duck Being Bitten: I just wanted to say, on this one, that it was possible. On my game, the Walker did land on them, and it's mouth was around Duck's waist when Lee looked up. Kat was just struggling with it, which caused it to move. What I don't get is, if it bit him, why wasn't half his side missing?
As stated, I know it's just a game. I just added these to add to the fun of the thread.