The difference between the game and comics? The game is a little more "kid friendly", but the they are pretty close.
If you're talking about the game and the TV show, the show was much more kid friendly and a bit more juvenile, and the voices were different obviously. Sam was still quite similar, although a little less gruff than the game. Max was a pretty different voice, with much less of that scratchy nasal voice.
There was a guy in Hit the road, that basicaly used the f-word as his vocabulary. It might have been edited, but it was like leisure suit larry 7, easy to know what he was saying.