Some choices did have a huge impact on me, although they weren't hard because my instincts kicked in right away.
1. Help Lilly/Kill Larry - the most affecting decision in the entire series... it is still hard to watch.
2. Save Doug or Carley - I hadn't yet become as resistant to those decisions as I am now, so this choice back then in ep. 1 was still tough. Although I didn't get to spend much time with Doug, it wasn't easy to let any of them die.
3. Ration the food - by far the hardest choice in the game... I was torn between what was right and what I wanted to do.
4. Having Clem shoot me or not wasn't as hard for me as choosing the appropriate things to say. I wanted to tell her so much things and there was just not enough time.
5. Stealing the food - this made me think what was indeed the right choice and now after I've finished playing I now that stealing the food the was the right choice for my group.
Most of the other choices were pretty easy for me.
Killed Duck - didn't care about Kenny at all, but I had to take care of Robin. The difficulty was not in the choice itself, but the moment.
Getting Lilly on the RV - the was the easiest choice for me. Of course I would take her back.
Chopping my arm - I didn't have some foolish dreams I would survive. I knew I was a goner and I needed my both hands if I was to save Clem. Plus, chopping my arm seemed like a bigger risk than anything else.
Showing the bite- I didn't hesitate for a second.
I do hope season two will present me with more difficult choices because including Kenny in a choice is not a choice at all