I think it'd be incredibly awesome if mid-game the group got caught in the crossfire of a battle between other groups, causing deaths and/or grudges by one/both the other groups.
I'd also like other people you can't necessarily have in your group but can interact with, similar to Vernon's group, where you can get them to help you against enemies, attack/steal from, trade with, converse with, have friendly relations with or start wars. That'd be one awesome part.
The game got involved with the water aspect. Have pirates, walkers coming out of the water(that'd be sick), a group come by boat in a panic, live on the waterfront and making runs on land, that sort of stuff.
A new setting. Get to a new town, a countryside, a new area in general. New state? Even better. Just my opinion.
Larger group. I liked approximately the group size at episode 1- early 2. Any smaller than that is fine for a time, but more-or-less, it'd be better if you were able to keep more people with you.
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"That little girl is in my care. We've been through more together than you can imagine. Anyone who tries to get between me and her-ANYONE- is gonna wind up dead! You hear me!?"
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