The art in Hit the Road had this stretched, zany feel to it. There weren't alot of straight edges in things, and it made you feel that there was something seriously wrong with the Sam and Max world (also in Day of the Tentacle). I like the art style that they used in HtR. It's that classic Lucasarts adventure game golden era stuff, and in my opinion it does seem to line up with the comics' tone.
All in all, everyone has something(s) that they feel that the game should have or not have, and I agree, there are definetely some things that ttg should not take any artistic liberties with, namely toning the humor down into that washed out drivel like the cartoons and dumbing down the adventure game mechanics. But, if they made it
just like Hit the Road or the comics with this and that little thing, they'd just be regurgitating the some old stuff. I'm looking forward to some new and creative things that'll be unique to this game, without violating the sanctity of the immutable, work that is HtR though