So, I just realized something: Max ditching his time-stream means there's now a New York City without the Freelance Police.
If the Sam & Max we hadn't played as strayed paths with the ones we have, then what does that mean exactly? I assume those two never came in contact with the events in What's New Beelzebub?, so the Soda Poppers might be in charge of Hell. Then the unseen, "Sam-becoming-a-monster" adventures happened, causing Hell's biggest suppliers to disappear off the face of the Earth.
So what's going on exactly? Did Hell go out of business? Did Skunkape arrive, take over the Earth, and obtain the Toys of Power? And does that mean Charlie Ho-Tep found a way to summon Junior?
Come to think of it, this might make an interesting Season 4.