I went through the Walking Dead on my Mac Mini last December. This week I installed 400 Days and played through that as well.
Now I'm trying to play the main game again from the start, and I am experiencing painfully long loading times between individual scenes. For an example, in Episode 1, the game is stuck loading for 30 seconds between every transition from one position to another at the Motor Inn. It's very annoying and distracts from the game play experience.
I did not have this problem in December, so I'm kind of baffled as to why this is happening. Could it be installing 400 Days did something? Or is it something with my Mac? Has anyone else experienced this problem, is there some way to make the game load more things at once, so it doesn't get stuck between every scene?