The moments when much is said with a little bit of animation, or when you notice a really good use of the camera, or when Clementine is just being plain adorable.
The entire burying of the boy in the attic, for example, is a great use of silence and meaning, with Lee looking at Clem and back at the boy, signifying his fear that it may one day be her grave he must fill.
A use of the camera I enjoy is when it zooms into the oncoming train when Kenny stops it from hitting the semi, and it stops on Kenny's face through the broken window, signifying that he is indeed broken on the inside after everything he's gone through. My interpretation, anyway. Other than that, it's just a cool shot.
The moment where Lee and Kenny walk to the clearing where they think Katjaa has taken care of Duck, and Lee looks up to see the bird flying overhead. My sister says it symbolizes Katjaa's spirit being freed, which I like very much, but I also feel it signifies the wish for freedom that Lee undoubtedly has at this point. A wish to be free of all the horrible things he and the group have gone through, contrasted with the reality that he has no choice but to walk forward to yet another horrible occurrence, one after another.
A small moment that I've grown to love is Carley's sad shaking of her head while everyone else looks horror-struck when Lee kicks Andy into the electric fence. I feel it's most dramatic when I've been playing Lee as a killer up until this point. To me, it communicates a sense of failure, as she has been the sole voice of comfort for Lee regarding his past up until this point, and is thus the only one who really wants to see him escape the demons of his past. So to see her disappointed and saddened by his actions gives the feeling that there may be no going back any longer for Lee.
And for some more positive examples, some Clementine moments. My sister loves what she calls, "the side eyes". When Lee is opening the door to see her discovery of the boat, Clementine turns her head slightly while still looking at the shed, making her look like this >_> but with a smile. :) Two moments I enjoy are Clementine's eyes moving up and down the cane of Lee's father as she asks "What's that?", and when she smiles and looks down slightly when Lee says he knows her parents are good because they raised her.
*sigh* Didn't expect it to go on so long, but I couldn't stop writing once I started thinking about all the moments I like, and there are still some I haven't mentioned. I'd like to hear more examples from you guys, or just give your thoughts and own interpretations on the ones I selected. Looking forward to reading more.